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KMID : 1812020230290040470
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Journal of Neurogastroenterology and Motility
2023 Volume.29 No. 4 p.470 ~ p.477
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Real-world Prescription Patterns and Patient Satisfaction Regarding Maintenance Therapy of Gastroesophageal Reflux Disease: An Observational; Cross-sectional, Multicenter Study
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Huh Cheal-Wung
Son Nak-Hoon
Youn Young-Hoon
Jung Da-Hyun
Kim Min-Kyung
Gong Eun-Jeong
Huh Kyu-Chan
Kim Seung-Young
Park Moo-In
Lee Ju-Yup
Kwon Joong-Goo
Kim Jae-Hak
Shin Cheol-Min
Jung Kee-Wook
Hong Su-Jin
Han Young-Sun
Choi Suck-Chei
Jung Hye-Kyung
Kim Hyun-Jin
Lee Kwang-Jae
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Abstract
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Background/Aims : Gastroesophageal reflux disease (GERD) is a common chronic gastrointestinal disorder that typically requires long-term maintenance therapy. However, little is known about patient preferences and satisfaction and real-world prescription patterns regarding maintenance therapy for GERD.
Methods : This observational, cross-sectional, multicenter study involved patients from 18 referral hospitals in Korea. We surveyed patients who had been prescribed proton pump inhibitors (PPIs) for GERD for at least 90 days with a minimum follow-up duration of 1 year. The main outcome was overall patient satisfaction with different maintenance therapy modalities.
Results : A total of 197 patients were enrolled. Overall patient satisfaction, patient preferences, and GERD health-related quality of life scores did not significantly differ among the maintenance therapy modality groups. However, the on-demand therapy group experienced a significantly longer disease duration than the continuous therapy group. The continuous therapy group demonstrated a lower level of awareness of potential adverse effects associated with PPIs than the on-demand therapy group but received higher doses of PPIs than the on-demand therapy group. The prescribed doses of PPIs also varied based on the phenotype of GERD, with higher doses prescribed for non-erosive reflux disease than erosive reflux disease.
Conclusion : Although overall patient satisfaction did not significantly differ among the different PPI maintenance therapy modality groups, awareness of potential adverse effects was significantly different between the on-demand and continuous therapy groups.
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KEYWORD
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Gastroesophageal reflux, Maintenance, Proton pump inhibitors
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